Since metals present in living organisms are trace in quantity, progress in bio-metal research depends highly on advances in measurement technology. If metals in biological samples, which are composed of complex matrices, can be detected with overwhelmingly high sensitivity and selectivity, unique applications in the fields of medicine and drug discovery can be expected. New analytical techniques that can be achieved by improving the sensitivity of instruments include a) simultaneous multi-element analysis and isotope analysis at the single-cell level, b) in-cell speciation, and c) single-cell elemental imaging. These techniques will not only measure the total amount of intracellular metals, but also provide information on 1) interactions between essential metals in living organisms and between essential metals and metals in drug candidate compounds, 2) interactions between metals and biomolecules, 3) spatial and temporal changes of intracellular metals, and so on. This information will be used for diagnosis by liquid biopsy, prevention of disease and resilience to aging, and other applications. The R051 committee aims to accelerate the development of new instruments and analytical techniques that cannot be achieved with existing technologies by deepening discussions among industry and academia on what needs to be solved.